Mute Broken When Mixing Console Used?

Hey guys, I’ve ran into an issue I’ve been unable to resolve. I’m running a Mackie ProFX10v3 with a EV RE20. During my broadcast if I hit the mic on XSplit to mute it, everyone can still hear me. I must reach over on the mixer and hit the mute on it.

I’ve used XSplit for 3 years broadcasting and this is the first real issue I’ve ran into. Muting at the mixer is just cumbersome when you’re controlling everything off a controller deck.

Thanks for any input.